Gene regulation involves the cooperative activity of multiple transcription factors (TFs) and co-activators that synergize to effect precise, context-dependent control of gene expression. The mechanisms of such cooperativity, particularly in the context of the cell’s many non-equilibrium processes, are poorly understood. I’m interested in using single-molecule tracking, genomics, and theory to map out the kinetic landscape of TF cooperativity.
Sathvik Anantakrish
